Characterization of bioactive metabolites from marine-derived fungi, Aspergillus aculeatus and Eurotium rubrumNattha Ingavat
( M.Sc. )
One new compound, aspergillusol A (1), a mixture of two new compounds, aspergillusols B (2a) and C (2b), together with a synthetically known compound, methyl ester of 4-hydroxyphenylpyruvic acid oxime (3), were isolated from a marine-derived fungus, Aspergillus aculeatus CRI323-04, while five known compounds, asperflavin (4), asperinine A (5), asperinine B (6), neoechinulin A (7), and L-alanyl-L-tryptophan anhydride (8), were isolated from Eurotium rubrum CRI255-01. Aspergillusol A (1) inhibits α-glucosidase from Saccharomyces cerevisiae. Compound 3 selectively exhibits cytotoxic activity against certain cell lines, but it is inactive toward normal cell line, MRC-5. Asperflavin (4), asperinine A (5), asperinine B (6), and neoechinulin A (7) exhibit cytotoxic activity, while L-alanyl-L-tryptophan anhydride (8) does not possess cytotoxic activitiy. Structure elucidation of all isolated compounds was accomplished by analyses of NMR, IR, UV, and MS spectra.
Aspergillus aculeatus/ Eurotium rubrum/ aspergillusol A/ aspergillusols B and C/ α-glucosidase inhibitor/ cytotoxic activity/ antimalarial activity