Isolation and characterization of bioactive compounds from Albizia lebbeck (L.) Benth. and Eurycoma longifolia JackKyaw Thet Oo
( M.Sc. )
The purpose of this research was to study bioactive compounds from two Thai medicinal plants, Albizia lebbeck and Eurycoma longifolia. This thesis describes the isolation, characterization and biological activities of isolated compounds from A. lebbeck and E. longifolia. By chromatographic separations, the crude methanol extract from the roots of E. longifolia yielded three compounds; compound El-01 (eurycomanol-2-O-β-D-glycopyranoside), compound El-02 (10-hydroxycanthin-6-one), and compound El-03 (eurycomanone). A triterpenoid compound Al-01 (betulinic acid) was isolated from the dichloromethane extract of A. lebbeck roots. Structures of all compounds were elucidated by analysis of their spectroscopic data. Antimalarial and cytotoxic properties of the isolated compounds were also evaluated.